Tasly medium development aims at revolutionizing current wide adaptation of traditional cell culture techniques for the preparation of cell therapy. Medicinally active cells are different from end-fate cells prepared under traditional culture systems. Medicinally active cells will be introduced into the human body, they have to be prepared with high quality without jeopardizing the efficiency of propagation. Therefore, Tasly media ensure:

a. Unique identity of specialized cell types derived from their tissue origins

b. Free of heterogeneity

c. High potency for personalized health rejuvenation

d. Aging resistance of cell products undergoing the passaging process

Property: Identification of different medicinally active cells, such as MSCs, relies on the characteristic signatures of cell-type-specific transcriptomic profiles. AI-aided integration of single-cell omics datasets laid the foundation for definition of the property of medicinally active cells.

Purity: The availability of medicinally active cells for a particularly personalized health rejuvenation must be free of heterogeneity, which is ensured by a designated culture condition and a thorough quality testing procedure.

Potency: Medicinally active cells must be of high potency for their designated application. Single cell omics analysis of a particular cell type ensures that only the final cell products of high potency can be released for personalized application.

Temporal and organ-specific alterations of homeostasis significantly affect the efficacy of personalized health rejuvenation. Organs-on-a-chip in combination with personalized proteomics and metabolomics constitute an analytical platform for the construction of personalized metabolomics profile. AI-aided strategic development helps define the right time window for intervention with medicinally active cells for personalized health rejuvenation.

Structural repair and functional rejuvenation of injured tissues by medicinally active cells require homing of the cells to the target tissue. Damaged vascular system, particularly microcirculation, prevents the homing process. Therefore, promotion of angiogenesis is critical for the re-establishment of microcirculation and homing of exogenously supplemented medicinally active cells. Tissue-specific pro-angiogenesis is the fundamental intellectual property of Tasly Institute of Life Rejuvenation.