Structural repair and functional rejuvenation of injured tissues by medicinally active cells require homing of the cells to the target tissue. Damaged vascular system, particularly microcirculation, prevents the homing process. Therefore, promotion of angiogenesis is critical for the re-establishment of microcirculation and homing of exogenously supplemented medicinally active cells. Tissue-specific pro-angiogenesis is the fundamental intellectual property of Tasly Institute of Life Rejuvenation.